Evaluation of pubertal and hormone development in boys who stored testicular tissue for fertility preservation before a treatment possibly leading to later fertility problems

Not Applicable

• Conditions: Childhood cancer, childhood hematological disease; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN13057463
• Lead Sponsor: niversitair Ziekenhuis Brussel

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-06-02
• Last Update Posted: 25 January 2021
• Study Completion: 2030-12-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: Male
• Target Recruitment: 100

Inclusion Criteria

Current inclusion criteria as of 11/01/2021:

1. Pre- and peripubertal boys (<18 years) who do not yet produce mature spermatozoa
2. Diagnosis of childhood cancer or childhood hematological disorders (<18 years) at the Universitair Ziekenhuis Brussel or the Hôpital Universitaire Des Enfants Reine Fabiola
3. High-risk gonadotoxic treatment (with an =80% risk of later fertility problems)
4. Did or did not undergo a testicular tissue biopsy procedure at a young age as a fertility preservation strategy

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Previous inclusion criteria:

1. Pre- and peripubertal boys (<18 years) who do not yet produce mature spermatozoa
2. Diagnosis of childhood cancer or childhood hematological disorders (<18 years) at the Universitair Ziekenhuis Brussel
3. High-risk gonadotoxic treatment (with an =80% risk of later fertility problems)
4. Did or did not undergo a testicular tissue biopsy procedure at a young age as a fertility preservation strategy

Exclusion Criteria

1. Diagnosis of testicular cancer

Study & Design

• Study Type: Observational
• Study Design: Not specified