Iris Tissue in Primary Congenital Glaucoma

Not Applicable

• Conditions: Primary Congenital Glaucoma
• Interventions: Procedure: Combined trabeculotomy-trabeculectomy with mitomycin c

• Registration Number: NCT04079725
• Lead Sponsor: Assiut University

Brief Summary

To present the histopathological features of the iris tissue in primary congenital glaucoma which may play a role in pathogenesis

Detailed Description

Primary congenital glaucoma etiology still remains obscure . originally barkan , and later Worst , proposed that a membrane covered the anterior chamber angle and blocked aqueous outflow , but the presence of that membrane has not been established histopathologically to date . Now most authors believe that the site of obstruction is the trabecular meshwork rather than an overlying membrane . Maldevelopment of the anterior segment is present in all forms of congenital glaucoma . this maldevelopment may involve the trabecular meshwork alone or the trabecular meshwork in combination with the iris or cornea or both. In approcimately 50% of patients , isolated trabeculodysgensis is the only developmental ocular anomaly found .This is the classic defect found in primary congenital glaucoma .These eyes have no developmental anomalies of iris or cornea present except abnormal insertion of the iris into the angle

Study Timeline

• Study First Submitted: 2019-08-30
• Study First Submitted QC: 2019-09-04
• Study First Posted: 2019-09-06
• Status Verified: 2020-10
• Last Update Submitted: 2020-10-20
• Last Update Posted: 2020-10-22
• Study Start: 2020-12
• Primary Completion: 2021-09
• Study Completion: 2022-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

1. Typical symptoms of epiphora , photophobia and blepharospasm
2. corneal diameter > 13 mm
3. Increased ocular tension > 25 mmHg UGA using schiotz tonometer

Exclusion Criteria

1. Infants with history of previous surgery
2. Secondary glaucoma
3. Glaucoma associated with other congenital anomalies

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Experimental : Infants with primary congenital glaucoma	Combined trabeculotomy-trabeculectomy with mitomycin c	-

Primary Outcome Measures

Name	Time	Method
Present histopathological features of iris tissue in infants with primary congenital glaucoma which may play a role in pathogenesis	2 years	Histopathological features of iris tissue in infants with primary congenital glaucoma who underwent Combined trabeculotomy-trabeculectomy with mitomycin C