Correlation of preoperative fluid status of patient (Inferior Vena Cava collapsibility) with preoperative fasting status, patient demography and general anaesthesia induced hypotension: a prospective, observational study

Completed

• Conditions: Abnormal findings in other body fluids and substances,

• Registration Number: CTRI/2020/10/028332
• Lead Sponsor: Hamdard Institute of Medical Sciences and Research

Brief Summary

Pre-existing hypovolemia is a known risk factor for postinduction hypotension. Of these, preoperative fasting is in particular, of interest to anaesthesiologist as it is readily modifiable. The effects of prolonged preoperative fasting on intravascular volume status needs to be determined. Ultrasound guided measurement of IVC collapsibility index (IVCCI) has been used to predict volume responsiveness and intraoperative hypotension in recent studies.

In this study we aim to determine the correlation of preoperative volume status, as assessed by ultrasound (abdominal subxyphoid / subcostal view) guided IVC diameter (dIVC) and IVCCI, with preoperative fasting and patient demographics. The correlation of dIVC and IVCC with post-induction hypotension will also be determined

It will be a randomized, prospective, observational, double blind study. Total of 110 consecutive adult  patients posted for surgery will be studied over a period of 6-9 months.

No previous studies are present on correlation of Inferior Vena Cava diameter and collapsibility with preoperative fasting status. Seasonal variation of the same has also never been studied. Any significant correlation found in this study can help in modifying fasting guidelines and predicting intraoperative hypotension in patients preoperatively.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-10
• Study Completion: 2021-12-24
• Last Update Posted: 2022-04-27

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

Consecutive adult patients of age 18 years and above,posted for elective non cardiac, non-obstetric surgery in Hakeem Abdul Hameed Centenary Hospital, New Delhi will be studied.

Exclusion Criteria

• ASA grade 3 or above 2.
• All pregnant patients and patients with intraabdominal mass 3.
• All patients on medication for hypertension 4.
• Patients with underlying cardiovascular disease, previous cardio-thoracic interventional procedures/ surgeries 5.
• Patients who cannot lie in supine position 6.
• Patients on positive pressure ventilation 7.
• Patients requiring central neuraxial block before induction of general anesthesia 8.
• Patients for emergency surgery.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.To determine the effect of preoperative fasting status on Inferior Vena Cava (IVC) diameter and IVC collapsibility	At the time of IVC ultrasound assessment. General Anaesthesia associated hypotension measured upto 15 minutes after induction of anaesthesia or till incision is given, whichever is earlier.
2. To determine the correlation between preoperative IVC collapsibility and general anesthesia associated hypotension.	At the time of IVC ultrasound assessment. General Anaesthesia associated hypotension measured upto 15 minutes after induction of anaesthesia or till incision is given, whichever is earlier.

Secondary Outcome Measures

Name	Time	Method
1. To determine the correlation between patient age and IVC diameter and collapsibility	2. To determine the seasonal variation in IVC diameter and collapsibility

Trial Locations

Locations (1)

Hamdard Institute of Medical Hakeem Abdul Hameed Centenary Hospital, New Delhi; 🇮🇳 South, DELHI, India

Hamdard Institute of Medical Hakeem Abdul Hameed Centenary Hospital, New Delhi

🇮🇳South, DELHI, India

Dr Jyotsna Agarwal

Principal investigator

9650252828

jyotsna_mamc@yahoo.com