Vaped Phenanthrene

Not Applicable

Not yet recruiting

• Conditions: Former Smoker; Non-Smoker

• Registration Number: NCT07134426
• Lead Sponsor: University of Minnesota

Brief Summary

Some people who used to smoke cigarettes continue to be at higher risk of developing lung cancer, even years after quitting. This study will look to see if a specific chemical, phenanthrene, is broken down in the lungs of former smokers through more harmful pathways than never-smokers. If former smokers break down chemicals that enter their lungs through more harmful pathways this might be putting them at higher risk for developing lung cancer even though they quit smoking. This information may help find better ways to prevent or treat cancer in the future.

This study is under an IND, but the drug is not being studied; instead, it is being used as a marker for drug metabolism.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-08
• Study First Submitted: 2025-08-14
• Study First Submitted QC: 2025-08-14
• Last Update Submitted: 2025-08-14
• Study First Posted: 2025-08-21
• Last Update Posted: 2025-08-21
• Study Start: 2025-10-01
• Primary Completion: 2027-09-01
• Study Completion: 2028-06-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• > 21 years of age
• In good physical & mental health
• In stable physical & mental health
• Have tried vaping
• Former daily cigarette smokers who quit 1-20 year ago
• Non-smokers who have not used tobacco or nicotine products

Exclusion Criteria

• Has any respiratory disease (ex - asthma, COPD, etc...)
• Has/had high blood pressure
• Has/had liver disease
• Has/had cancer
• Has experience negative effects when vaped previously
• Pregnant or nursing

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Urinary Ratio of D10PheT/D9PhOH	24 hours after vaping phenanthrene	The ratio of D10-phenanthrene tetraol to D9-phenanthrene phenols in the urine will determine how the lung breaks down a class of cancer-causing chemicals called Polycyclic Aromatic Hydrocarbons (PAHs). The higher this ratio the more the lungs break down these chemicals through harmful pathways, which might increase cancer risk. The lower the ratio the more the lung breaks down the chemicals through safer pathways.
TNE	Baseline measure	Total nicotine equivalents will be measured in the urine samples to confirm that study participants are not using tobacco or nicotine products.

Trial Locations

Locations (1)

University of Minnesota; 🇺🇸 Minneapolis, Minnesota, United States