rhTSH and T3 stimulation tests in offspring of long-lived siblings and their partners

Completed

• Conditions: schildkliermetabolisme en weefselregeneratie in groepen die verschillen in familiaire langlevendheid; healthy ageing; thyroid metabolism

• Registration Number: NL-OMON45854
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Couples will be recruited from the Leiden Longevity Study (LLS), preferably from the 135 subjects that previously participated in the Switchbox phase 1 study, and preferably from the subgroup of 20 couples that were recruited for Group A (P11.116 * Switchbox). All subjects participating in Switchbox phase 1 were healthy, middle-aged (55-77 years) males or females with a BMI in the range of 22.5 kg/m2 to 33 kg/m2. Each couple participating in LLS consists of a child from a family enriched for longevity (case, offspring of long-lived sibling) and his/her current partner (control).

Exclusion Criteria

* Cardiac arrhythmias
* (History of) thyroid diseases
* TSH hoger dan 4.0 mU/l
* fT4 level outside the normal range (9-24 pmol/l)
* Any significant chronic disease
* Renal, hepatic or endocrine disease
* Hormone therapy
* Difficulties to insert an intravenous cannula
* Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year
* (History of) alcohol abuse (meer dan 28 units per week)
* Nicotine abuse

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome parameters of the study are the (precursor) hormones reflecting<br /><br>the physiological response of the thyroid gland after TSH or T3 stimulation,<br /><br>namely T3, T4, fT3, fT4, Tg and TSH. The levels of these hormones will be<br /><br>compared between offspring of long-lived families and their partners.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome parameters of the study are processes potentially influenced<br /><br>by thyroid metabolism, namely tissue regeneration, body temperature regulation,<br /><br>heart rate and metabolomics. </p><br>