Effect of zinc supplementation in major depressio

Not Applicable

• Conditions: Major Depression.; Severe depressive episode without psychotic symptoms

• Registration Number: IRCT201110187836N1
• Lead Sponsor: Department of Clinical Nutrition and Diet therapy, Faculty of Nutrition Sciences and Food Technology

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

Inclusion Criteria:
- A diagnosis of major depressive disorder
- Have no current medical illness (diabetes, cancer, cardiovascular, inflammatory, liver or renal diseases)
- No antepartum or postpartum depression
- Current treatment with medication except for depressive disorder
- Current use of multivitamin-mineral supplement

Exclusion criteria:
- pregnancy or lactation
- any change in medication
- A diagnosis of a new medical illness during study

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Depression. Timepoint: at the begining, after 6 and 12 weeks of supplementation. Method of measurement: Hamilton and Beck Depression Rating Scale.

Secondary Outcome Measures

Name	Time	Method
Plasma concentration of brain-derived growth factor. Timepoint: Before and after 12 weeks of treatment. Method of measurement: Biochemical assay.;Plasma concentration of Tumor Necrosis Factor-a. Timepoint: Before and after 12 weeks of treatment. Method of measurement: Biochemical assay.;Plasma concentration of Interleukin-6. Timepoint: Before and after 12 weeks of treatment. Method of measurement: Biochemical assay.