Intranasal ketamine versus intravenous morphine for older adults with musculoskeletal pain in the emergency department: a randomized controlled trial

Phase 3

Recruiting

• Conditions: acute musculoskeletal pain in elderly; musculoskeletal muscle pain older elderly

• Registration Number: TCTR20201229004
• Lead Sponsor: navamindradhiraj research fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-29
• Study Completion: 2021-12-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Patient age more than 65 years presenting to the ED
2. Musculoskeletal pain within 7 days
3. Moderate to severe pain(Numeric rating scale 5-10)

Exclusion Criteria

1. Lack of Informed consent
2. Hemodynamic instability ( SBP < 90 or > 180 mmHg, PR < 50 or > 150 bpms, RR < 10 or > 30 bpms)
3. History of acute head or eye injury
4. Seizure
5. Intracranial hypertension
6. Severe chronic obstructive pulmonary disease
7. Chronic pain
8. Psychological disorder
9. Immediate surgical intervention
10. Altered mental status
11. Alcohol and drug abuse
12. Nasopharyngeal deformity
13. Recent opioid use (4 hr before)
14. Ketamine and morphine allergy/addiction
15. Renal (CrCl <50) or hepatic insufficiency
16. Patients with a history of risk or exposure to COVID-19 disease according to the notification of the Department of Disease Control.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
difference of numeric pain scale in patients who receive morphine and ketamine 0, 15, 30,45,60,75,90,105,120 min percentage

Secondary Outcome Measures

Name	Time	Method
adverse event and rate of rescue therapy after medication 0, 15, 30,45,60,75,90,105,120 min percentage