Modified citrus pectin as therapy in heart failure

Not Applicable

• Conditions: Heart failure; Circulatory System

• Registration Number: ISRCTN49496801
• Lead Sponsor: Hull and East Yorkshire Hospitals NHS Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-07-09
• Study Completion: 2017-01-01
• Last Update Posted: 5 May 2019

Recruitment & Eligibility

• Status: Stopped
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Patients diagnosed with heart failure, who had been or are currently on diuretics, substantiated by a raised NT-pro BNP and /or evidence of left ventricular systolic or diastolic dysfunction
2. Plasma galectin-3 level > 17.8 ng/mL
3. Therapy with an angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) and beta-blocker (BB) (unless documented intolerance) for at least 3 months duration.
4. Aged over 18
5. If female, not of childbearing age or, if of childbearing age and sexually active, willing to use birth control.

Exclusion Criteria

1. Current decompensated heart failure
2. Inability to provide informed consent
3. Use of eplerenone or spironolactone within 30 days of randomization or for more than 7 days within the previous 6 months (because they suppress galectin-3 effects and have potassium sparing effects which could increase the risk of hyperkalemia)
4. Pregnant or breast-feeding women

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Current primary outcome measures as of 27/10/2014:<br> 1. Effect of MCP supplementation on NT-proBNP (primary endpoint of the study). Natriuretic peptides such as NT-proBNP increase in response to myocardial stretch<br> 2. Effect of MCP supplementation on collagen turnover and extracellular remodelling (PICP)<br><br> Previous primary outcome measures:<br> 1. Effect of MCP supplementation on NT-proBNP (primary endpoint of the study). Natriuretic peptides such as NT-proBNP increase in response to myocardial stretch<br> 2. Effect of MCP supplementation on collagen turnover and extracellular remodeling<br> 3. Global longitudinal strain<br>