Cognitive Impairment and Upper Extremity Performance in COPD

• Conditions: Cognitive Impairment; Upper Extremity; Upper Limb Function; COPD
• Interventions: Other: Functional tests

• Registration Number: NCT05137483
• Lead Sponsor: Izmir Katip Celebi University

Brief Summary

Within the scope of this study, COPD patients will be divided into two groups according to cognitive dysfunction.

Pulmonary function test, COPD assessment scale, Mini-Mental State Examination and Montreal Cognitive Assessment Scale, 6 min pegboard ring test, grip strength measurement, Fatigue Impact Scale and St.George Respiratory Questionnaire will be applied to the groups.

Detailed Description

Although the mechanism of cognitive dysfunction in COPD is not clear, the reasons focused on are; decreased oxygen use, high carbon dioxide levels, increased inflammation and oxidative stress, decreased physical activity, peripheral vascular diseases, atherosclerosis, high or low blood pressure, cerebral vasoconstriction, increased intracranial pressure, accompanying comorbidities, smoking and genetic predisposition, brain damage and exacerbations have been reported. Few studies have shown that cognitive dysfunction is associated with functional performance. There are no studies on the effect of cognitive function on upper extremity performance and mechanisms of action in COPD patients.

The aim of this study is to compare upper extremity functional capacities, respiratory functions, fatigue and quality of life in COPD patients with and without cognitive function impairment.

Within the scope of this study, COPD patients will be divided into two groups according to cognitive dysfunction.

Pulmonary function test, COPD assessment scale, Mini-Mental State Examination and Montreal Cognitive Assessment Scale, 6 min pegboard ring test, grip strength measurement, Fatigue Impact Scale and St.George Respiratory Questionnaire will be applied to the groups.

Study Timeline

• Status Verified: 2021-11
• Study First Submitted: 2021-11-18
• Study First Submitted QC: 2021-11-18
• Last Update Submitted: 2021-11-18
• Study Start: 2021-11-19
• Study First Posted: 2021-11-30
• Last Update Posted: 2021-11-30
• Primary Completion: 2022-06-30
• Study Completion: 2022-07-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Volunteering to participate in the study
• Stage 2-3-4 according to the GOLD classification in the 40-65 age range

Exclusion Criteria

• Exacerbation of respiratory symptoms in the past 4 weeks (change in breathlessness and/or sputum volume/color, need for antibiotic treatment or need for hospitalization)
• Presence of asthma, unstable coronary heart disease, uncontrolled diabetes, hypertension, left-sided congestive heart failure, neoplasia, severe claudication, encephalitis or epilepsy
• Having a history of head trauma or brain tumor
• Having a significant psychiatric condition or the presence of defined dementia, according to the American Psychiatric Association

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
With cognitive impairment	Functional tests	Pulmonary function test, COPD assessment scale, Mini-Mental State Examination and Montreal Cognitive Assessment Scale, 6 min pegboard ring test, grip strength measurement, Fatigue Impact Scale and St.George Respiratory Questionnaire will be applied to the group.
without cognitive impairment	Functional tests	Pulmonary function test, COPD assessment scale, Mini-Mental State Examination and Montreal Cognitive Assessment Scale, 6 min pegboard ring test, grip strength measurement, Fatigue Impact Scale and St.George Respiratory Questionnaire will be applied to the group.

Primary Outcome Measures

Name	Time	Method
6 min. pegboard ring test	6 minutes	It is used to measure upper extremity functional capacity.

Secondary Outcome Measures

Name	Time	Method
Mini Mental State Test	15 minutes	It is used for measuring cognitive impairment
mMRC Dyspnea Scale	5 minutes	It is used for measuring dyspnea sensation in daily living activities
Montreal Cognitive Assessment Scale	30 minutes	It is used for measuring cognitive impairment
Fatigue Impact Scale	Time Frame: 20 minutes	It is used for measuring fatigue level
COPD Assessment Test	10 minutes	It is used for measuring health status of COPD patients
St. George Respiratory Questionnaire	20 minutes	It is used for measuring desase-related quality of life
Respiratory Function Test	20 minutes	It is used for measuring lung functions and respiratory muscle strength