The effect of preoperative sildenafil on operative and early postoperative outcome after mitral valve replacement in patients with pulmonary hypertens

Not Applicable

Recruiting

• Conditions: Circulatory System; pulmonary hypertension, cardiac surgery

• Registration Number: PACTR201703002106114
• Lead Sponsor: Cardiothoracic surgery department - Faculty of Medicine - Menoufia University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-03-15
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients who will be scheduled for elective mitral valve replacement surgery with pulmonary hypertension (pulmonary artery systolic pressure(PASP) ¿50mmHg)

Exclusion Criteria

Co-existing coronary artery diseases.
Emergency mitral valve replacement.
Redo mitral valve replacement.
Congestive heart failure.
Renal dysfunction, creatinine > 2 mg / dl.
Hepatic dysfunction, bilirubin > 3 mg /dl.
Chronic obstructive pulmonary disease, FEV1/FEVC< 7.
Concomitant aortic valve replacement.
Severe tricuspid regurgitation.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
effect of oral Sildenafil on lowering pulmonary hypertension preoperative