The effect of dexmedetomidine as adjuvant analgesia on postoperative delirium, and perioperative and postoperative arrythmia and hemodynamics in opium user patients undergoing open heart surgery

Phase 4

• Conditions: Condition 1: post operative delirium. Condition 2: cardiac surgery complications.; Other delirium; Unspecified complication of cardiac and vascular prosthetic device, implant and graft; F05.8; T82.9

• Registration Number: IRCT20230603058373N1
• Lead Sponsor: Semnan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

history of opium addiction
candidate for elective open heart surgery

Exclusion Criteria

weight<50kg
history of trauma or neurological lesions
liver failure
dexmedetomidine allergy
EF<30%
aortic pump requirement
any unpredictable circumstances or pump failure during surgery
aortic clamp>2h
history of cerebral stroke
Impaired level of consciousness
history of heart failure
kidney failure or history of dialysis

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Delirium. Timepoint: daily. Method of measurement: confusion assessment method.;Arrhythmia. Timepoint: perioperative and postoperative. Method of measurement: checklist.

Secondary Outcome Measures

Name	Time	Method
Postoperative pain. Timepoint: every 4h. Method of measurement: visual analog scale.;Cognitive function. Timepoint: preoperative and postoperative. Method of measurement: mini mental state exam.