PROVE: PReeclampsia Obstetric adVerse Events
试验速览
- 阶段
- 未知
- 状态
- 进行中（未招募）
- 入组人数
- 300
研究概览
简要总结
2021 Other publications in https://pubmed.ncbi.nlm.nih.gov/33744176/ case control study (added 22/10/2021) 2021 Other publications in https://pubmed.ncbi.nlm.nih.gov/34392166/ observational study of blood pressure as a risk factor for eclampsia (added 22/10/2021) 2021 Other publications in https://pubmed.ncbi.nlm.nih.gov/33492667/ observational study of cognitive impairment in preeclampsia (added 22/10/2021) 2021 Protocol article in https://pubmed.ncbi.nlm.nih.gov/33924230/ protocol (added 22/10/2021) 2022 Other publications in https://doi.org/10.1161/jaha.121.024395 Associations Between Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia (added 02/11/2023) 2022 Other publications in https://doi.org/10.1016/j.ajog.2022.03.009 Cardiac magnetic resonance imaging in preeclampsia complicated by pulmonary edema shows myocardial edema with normal left ventricular systolic function (added 02/11/2023) 2022 Other publications in https://doi.org/10.1016/j.ajog.2022.02.036 Cerebral biomarkers in neurologic complications of preeclampsia (added 02/11/2023) 2023 Other publications in https://doi.org/10.1210/endocr/bqad041 Circulating Chemerin Is Elevated in Women With Preeclampsia (added 02/11/2023) 2021 Other publications in https://doi.org/10.1161/jaha.120.020302 Circulating Growth Differentiation Factor 15 Is Increased Preceding Preeclampsia Diagnosis: Implications as a Disease Biomarker (added 02/11/2023) 2022 Other publications in https://doi.org/10.3389/fphys.2022.1022770 Circulating concentrations of glycocalyx degradation products in preeclampsia (added 02/11/2023) 2023 Other publications in https://doi.org/10.1016/j.preghy.2022.12.001 Correlation between cognitive assessment scores and circulating cerebral biomarkers in women with pre-eclampsia and eclampsia (added 02/11/2023) 2021 Other publications in https://doi.org/10.3390/cells10113045 Evidence of Neuroinflammation and Blood-Brain Barrier Disruption in Women with Preeclampsia and Eclampsia (added 02/11/2023) 2022 Other publications in https://doi.org/10.1161/jaha.121.024536 PSG7 and 9 (Pregnancy-Specific ß-1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia (added 02/11/2023)
研究设计
- 研究类型
- Observational
入排标准
- 性别
- Female
入选标准
- •1.1. Women with a diagnosis of preeclampsia or severe preeclampsia in gestational week 20-42
- •1.2. Admitted to Tygerberg hospital
- •Severe preeclampsia is defined as preeclampsia with an organ complication such as renal failure, pulmonary oedema, eclampsia, intracerebral hemorrhage, cerebral oedema, heart failure or disseminated intravascular coagulation
- •2. Controls:
- •2.1. Women with healthy pregnancies matched for gestational age admitted for delivery at Tygerberg hospital
- •Both primiparous and parous women are included
排除标准
- •1. Cases: If the woman is not able to give informed consent
- •1.1. For women with pulmonary edema: Existing cardiac disease
- •1.2. For women with eclampsia: Existing neurological disease
- •2. Normotensive controls:
- •2.1. Pre-exisiting hypertension
- •2.2. Diabetes mellitus before or during pregnancy
- •2.3. Pre-exisiting cardiovascular, renal or cerebral disease
- •2.4. Chronic medication