Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer
- Conditions
- Colonic Neoplasms
- Registration Number
- NCT00516230
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
Correct identification of Lynch syndrome at the time of colorectal cancer presentation is important. We aim to find best ways to screen patients with colorectal cancer in Korea.
- Detailed Description
Patients with newly diagnoised colorectal cancer will be eligible. They will undergo detailed history taking including family history, and molecular stuidies including microsatellite instability test and immunohistochemistry for DNA mismatch repair protein with pre-selection. Any abnormal finding in molecular stuides will be offered genetic testing (after testing methylation status for patients with abnormalities in MLH1).
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
- Colorectal cancer
Exclusion Criteria
- Histology showing other than adenocarcinoma
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Samsung Medical Center
🇰🇷Seoul, Gangnam-gu, Korea, Republic of