Elucidation of the relationship between cancer cachexia progression and CYP3A4 and OATP1B activity
Not Applicable
- Conditions
- Cancer Cachexia
- Registration Number
- JPRN-UMIN000044390
- Lead Sponsor
- facluty of medicine, Oita University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Not provided
Exclusion Criteria
Patients who are concomitantly using drugs that induce or inhibit CYP3A and OATP1B. Patients with hepatic/renal dysfunction.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluation of the effect of cancer cachexia progression on CYP3A4 and OATP1B activity
- Secondary Outcome Measures
Name Time Method 1) Relationship between cancer cachexia progression and plasma concentration, the endogenous substrate for CYP3A4. 2) Relationship between cancer cachexia progression and plasma concentration, the endogenous substrate for OATP1B. 3) Relationship between plasma concentration of the endogenous substrate and inflammatory cytokine concentration. 4) Relationship between plasma concentration of the endogenous substrate and inflammatory cytokine concentration. 5) Relationship between Phenotype of CYP3A5 gene polymorphism and plasma concentration of the endogenous substrate, various inflammatory cytokine concentrations, and cancer cachexia progression. 6) Relationship between Phenotype of OATP1B gene polymorphism and plasma concentration of the endogenous substrate, various inflammatory cytokine concentrations, and cancer cachexia progression.