Influence of Bedrest and Hypocaloric Nutrition on Endothelium-Dependent Vasoreactivity
- Conditions
- Healthy
- Registration Number
- NCT00175968
- Lead Sponsor
- Heidelberg University
- Brief Summary
Aim of the study is to assess the impact of the factors ´bed rest´ and ´hypocaloric nutrition´ on endothelium-dependent vasoreactivity in healthy volunteers.
- Detailed Description
In a randomized, four-phase cross-over study the effect of simulated microgravity (13 days of bed rest), energetic restriction (-25%, fat reduced), and their combination on endothelium-dependent and -independent vasodilation will be compared with ambulatory control conditions. Using venous occlusion plethysmography cumulative intraarterial dose-response curves to endothelium-dependent (acetylcholine) and -independent (sodium nitroprusside) vasodilators will be constructed in 10 healthy male volunteers before and on day 13 of each of the four intervention periods.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 10
´
- Healthy, male volunteers, age: 18-40
- Able and willing to give written informed consent
- Known condition causing endothelial dysfunction (e.g. diabetes, hyperlipidaemia, arterial hypertension, smoking, hyperhomocysteinaemia)
- Regular medication and/or treatment with drugs within the last 4-6 weeks (exclusion has to be decided in each case)
- Acute or chronic illness
- Participation in clinical trial/blood donation within 2 month before the study
- Nicotine during 1 year before the study; drug and/or alcohol abuse.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Drug-induced changes of forearm blood flow
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
DLR Institute of Aerospace Medicine
🇩🇪Cologne, North-Rhine-Westphalia, Germany