Mucosal Microbiome in Human Gastric Intestinal Metaplasia and Duodenal Tissue.

• Conditions: Gastric Intestinal Metaplasia; Duodenum; Mucosal Microbiome
• Interventions: Other: endomicroscopy, targeted biopsy and 16s rRNA gene sequencing

• Registration Number: NCT02428426
• Lead Sponsor: Shandong University

Brief Summary

To investigate the mucosal microbiome in human gastric intestinal etaplasia and duodenal tissue.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-09
• Status Verified: 2015-04
• Study First Submitted: 2015-04-23
• Study First Submitted QC: 2015-04-23
• Last Update Submitted: 2015-04-23
• Study First Posted: 2015-04-28
• Last Update Posted: 2015-04-28
• Primary Completion: 2015-07
• Study Completion: 2015-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Patients scheduled for gastroendoscopy examination Aged between 18 and 80 years old

Exclusion Criteria

• Antibiotic, probiotic or prebiotic usage within 2months,gastric inhibitor usage within 1 month Esophageal, gastric or duodenal cancer or other malignancy History of upper GI tract surgery Coagulopathy or bleeding disorders Allergy to fluorescein sodium Pregnant or breast-feeding (for females) Impaired renal function

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
gastritis	endomicroscopy, targeted biopsy and 16s rRNA gene sequencing	patients were diagnosed non atrophic gastritis
gastric intestinal metaplasia	endomicroscopy, targeted biopsy and 16s rRNA gene sequencing	patients were diagnosed gastric intestinal metaplasia

Primary Outcome Measures

Name	Time	Method
The operational taxonomy units in gastric Intestinal Metaplasia and and Duodenal mucosal microbiome	6 months

Trial Locations

Locations (1)

Department of Gastroenterology, Qilu Hospital, Shandong University; 🇨🇳 Jinan, Shandong, China