Adaptive Cognitive Training in Healthy Older Adults

Not Applicable

Completed

• Conditions: Mild Cognitive Impairment; Mild to Moderate Dementia; Alzheimer's Disease
• Interventions: Other: Computerized games; Other: Computerized cognitive training

• Registration Number: NCT02205710
• Lead Sponsor: Bruyere Research Institute

Brief Summary

Cognitive training has emerged as a promising method to maintain, enhance, and rehabilitate cognitive function in older adults and individuals with dementia. In recent years, such training has become particularly appealing in the clinical context, with many paradigms aimed specifically at adults experiencing various stages of cognitive decline due to Mild Cognitive Impairment, Alzheimer's disease, and vascular dementias. However, basic questions remain. For example, uncertainty persists regarding factors that influence observed improvements as well as the conditions that would maximize transfer and sustainability of training effects. The objective of this study is to evaluate factors that may maximize the benefits of computerized cognitive training in older adults.

Detailed Description

The study involves 25 sessions of an adaptive cognitive training program, completed over 5 weeks. Pre and post training assessments will evaluate any near and far transfer effects of training.

Study Timeline

• Study First Submitted: 2014-07-29
• Study First Submitted QC: 2014-07-30
• Study First Posted: 2014-07-31
• Study Start: 2016-08
• Status Verified: 2017-08
• Primary Completion: 2018-08
• Study Completion: 2018-08
• Last Update Submitted: 2019-07-31
• Last Update Posted: 2019-08-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 99

Inclusion Criteria

• English as the maternal or primary spoken language.
• Good self-reported health (i.e., no cerebro-, or cardio-vascular disease or neurological disease).
• Normal or corrected-to-normal vision and hearing.

Exclusion Criteria

• Poor hearing or vision
• Inadequate understanding of the English language

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Computerized game training	Computerized games	Series of gamified tasks.
Computerized cognitive training	Computerized cognitive training	Series of gamified tasks.

Primary Outcome Measures

Name	Time	Method
Change in neural activity	Baseline, week 5	We will measure resting state as well as task-related EEG responses to determine the effects of cognitive training at the neural level.
Change in ratings on cognitive training survey	Baseline, week 5	This survey aims to assess participant perceptions on cognitive training, and includes a series of related questions, rated on a scale of 1-7.
Change in performance on neuropsychological tests	Baseline, week 5	Using a set of standard neuropsychological evaluations, we will measure changes in attention, memory, and executive function following cognitive training.

Secondary Outcome Measures

Name	Time	Method
Change in ratings of psychological wellbeing	Baseline, week 5	We will use standardized questionnaires to assess quality of life, in order to measure the influence of cognitive training on factors related to wellbeing.

Trial Locations

Locations (1)

Bruyere Continuing Care; 🇨🇦 Ottawa, Ontario, Canada