Attention Training for Learning Enhancement and Resilience Trial
- Conditions
- Age-related Cognitive Decline
- Interventions
- Other: Computerized Plasticity-Based Adaptive Cognitive TrainingOther: Commercially available computerized training
- Registration Number
- NCT02416401
- Lead Sponsor
- Posit Science Corporation
- Brief Summary
Healthy aging is associated with a decline in multiple cognitive domains, as well as motor control function. The long-term consequences of cognitive and functional impairment resulting from age-related cognitive decline are well documented in the scientific and clinical literature, with significant evidence of related problems with independent functional abilities. This study aims to understand how the experimental computer program can affect cognition and attention in participants with age-related cognitive decline.
- Detailed Description
Following consent, participants will engage in an assessment process to determine eligibility. Once eligibility is confirmed, participants will be scheduled for another assessment session to determine current level of cognitive function. This process consists of paper-pencil surveys and computerized tests. Following the assessment process, participants will engage in an Internet browser-delivered training sessions conducted on any internet-accessible computer. The computerized training sessions can be done up to 7 times a week (once a day) or at the participant's convenience (the recommended time commitment is 5 times a week). Following the completion of training, the participant's cognitive function will be re-assessed. Participation is voluntary and participants may withdraw from the study at any time.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 83
- Participants must be 65 years of age or older
- Participants must have a diagnosis of age-related cognitive decline as confirmed by interview and performance on screening assessments
- Participants must be fluent English speakers
- Participants must have adequate visual, auditory, and motor capacity to use computerized intervention
- Participants with diagnosis of PTSD, depression or other psychologically diagnosable emotional disorder
- Participants with a history of conditions that could affect thinking abilities, including brain injury, mental illness, cancer, or other neurological conditions (multiple sclerosis, seizure disorder), HIV/AIDS will be excluded
- Participants enrolled in another concurrent research study will be excluded
- Participants who have difficulty performing assessments or comprehending or following spoken instructions, in the judgment of the screening clinician, will be excluded
- Participants with a current or significant past history of substance abuse will be excluded
- Participants who show signs of suicidal ideations or behaviors will be excluded and referred for appropriate treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Experimental Treatment Computerized Plasticity-Based Adaptive Cognitive Training Computerized plasticity-based adaptive cognitive training requiring a total maximum of 36 treatment sessions, 4-5 times weekly, one hour each session. Active Comparator Commercially available computerized training Commercially available computerized training requiring a total maximum of 36 treatment sessions, 4-5 times weekly, one hour each session.
- Primary Outcome Measures
Name Time Method Attention Measures aimed to test attention 6 months Measures aimed to test attention
Functional Capacity 6 month Performance on directly observable functional measure
Executive Function 6 months Tasks targeting inhibitory control
- Secondary Outcome Measures
Name Time Method Quality of Sleep 6 months assessing sleep quality
Trial Locations
- Locations (2)
Harvard Medical School
🇺🇸Boston, Massachusetts, United States
University of Iowa
🇺🇸Iowa City, Iowa, United States