To Assess the Bone Regeneration in extraction sockets using Simvastatin in comparison to Rosuvastatin : a Randomized Control Trial

·        Tooth loss affects the quality of life as it leads to ineffective mastication ,altered speech, concern about the appearance ,  loss of self confidence.·        Partial or complete edentulism leads to bone resorption making rehabilitation difficult.·        Following tooth extraction ,Several  Interventions that involve autografts, allografts, xenografts, guided bone regeneration (GBR) and growth factors have been used with varying degrees of success in an effort to maintain the anatomical dimensions of the alveolus before implantation.·        Although autograft is considered gold standard there is risk of donor site morbidity , pain , infection , scarring , etc. ·        Commonly used  xenograft have higher risk of the immunological reaction and  infection, etc.·        There is a constant search for the ideal graft material ·        Mundy G et al (1999) examined several compounds and found that Statin drugs like simvastatin used for lowering serum cholesterol increased the expression of bone morphogenetic protein-2 (BMP-2) gene in bone cells which leads to bone formation.·        Rosuvastatin is a 2nd generation , hydrophilic stain which has demonstrated bone regeneration properties in furcation defects: hence the aim of this  study is to assess efficacy of Simvastatin and Rosuvastatin in regeneration of the bone after the extraction of the teeth.