Evaluation of changes in extraction socket of tooth after filling with tooth powder mixed with blood derived product

Phase 4

Completed

Conditions: Illness, unspecified,

Registration Number: CTRI/2019/10/021714

Lead Sponsor: All India Institute of Medical Sciences

Brief Summary: Replacement of missing or extracted teeth by implants in anatomically, aesthetically, and long term functional restorative positions depend on having adequate bone and soft tissue dimensions both vertically and horizontally. Tooth extraction produces resorption and remodelling of socket dimensions which reduce bone volume available for implant placement subsequently. Even immediate placement of implant into socket sites will not prevent the loss of hard tissue dimension inside the socket wall.

Socket grafting to minimize the volume changes of socket i.e. Socket or Ridge Preservation has been reported with a number of filler materials being used, including allografts, xenografts, alloplasts, and bioactive materials such as bone morphogenetic proteins and platelet rich fibrin. Use of autologous tooth graft has gained wide popularity in last few years and has demonstrated bone regeneration in histomorphometric studies. Among the platelet derived products, injectable Platelet-rich Fibrin (iPRF) offers the characteristics of advanced PRF as a liquid. It contains high quantities of growth factors which stimulates cell proliferation and up-regulates angiogenesis. When injectable PRF is injected onto the bone graft, it gets adsorbed on the graft particles to form a cohesive mass. It may be hypothesized that a mixture of autogenous tooth bone graft and bioactive material (iPRF) may results in an increased percentage of vital bone formation.

Furthermore, the quality of augmented bone in extraction socket is the determinant of primary implant stability during implant placement and a critical factor in determining the success of dental implants. To date there is no research which has evaluated the quality of bone formation in extraction sockets grafted with ATBG mixed with iPRF and its clinical correlation with the primary implant stability. Therefore, aim of the present study is to evaluate the clinical, radiographic, and histomorphometric analysis of autogenous tooth bone graft mixed with injectable platelet rich fibrin for ridge preservation.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 42

Inclusion Criteria

b)Patients who have a clinically determined need for extraction of single rooted non-molar tooth (root or crown fractures, non-restorable caries and residual roots).
followed by an implant supported restoration c)Patients who will be available for further follow up.
d)Adequate restorative space for implant-supported restoration e)Presence of at least one tooth on each side to the tooth to be extracted.
f) â‰¥ 10-mm distance of alveolar bone crest from the base of the socket.
g)Root location and angulation that would be consistent with the subsequent implant placement.

Exclusion Criteria

a)Inability or anticipated failure to maintain adequate oral hygiene b)Pregnant or lactating mothÂ¬ers c) Patients with other systemic conditions (uncontrolled diabetes, unstable bleeding disorders, active infectious diseases; hepatitis, tuberculosis, HIV etc.) that could affect the healing ability of wound.
d)Mental disabilities that may hinder participation.
e)Active immunosuppressive therapy, cancer therapy and/or radiation to the oral cavity within the past 6 months f)Patients with acute dental infection of bone and ankylosed teeth.
g)Conditions/medications contraindicated for bone regeneration (e.g. methotraxate, cyclosporine A, steroids, bisphosphonates).
h)Multirooted teeth because of the potential for presence of interradicular bone that might be harvested as part of the core biopsy procedure.
i)Loss of more than 50% of buccal plate at the time of extraction.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postextraction dimensional and histologic changes in grafted sockets	4 months

Secondary Outcome Measures

Name	Time	Method
Maximum insertion torque value during implant placement and radiographic bone density	4 months

Trial Locations

Locations (1): All India Institute of Medical Sciences
🇮🇳
South, DELHI, India
All India Institute of Medical Sciences
🇮🇳South, DELHI, India
Dr Vikender Singh
Principal investigator
8800798248
vikenderyadav@gmail.com