To compare the effect of two drugs dexmedetomidine and lignocaine on decreasing cough response after anaesthesia in patients undergoing surgery for brain tumors.
Phase 4
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2024/01/061334
- Lead Sponsor
- ttar pradesh university of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA I or II class, BMI less than 30,
Undergoing elective craniotomy for intracranial tumor under general anaesthesia.
Exclusion Criteria
1. Patient Refusal
2. Renal impairment
3. Cardiorespiratory abnormalities
4.Bronchial asthma COPD
5. Restrictive lung diseases
6. Liver failure
7. Allergy to drugs will be used
8. Pregnancy-lactation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To compare the effect of intratracheal dexmedetomidine and intratracheal lignocaine on the emergence cough response by using the emergence cough scoreTimepoint: 5 min after extubation
- Secondary Outcome Measures
Name Time Method <br/ ><br>Hemodynamic parameters Heart rate,Mean blood pressure, and Oxygen saturationTimepoint: <br/ ><br>Baseline (T0) <br/ ><br> <br/ ><br>15 min before extubation (at the time of intervention drug given) (T1) <br/ ><br> <br/ ><br>10 min before extubation (T2) <br/ ><br> <br/ ><br>5 min before extubation (T3) <br/ ><br>At the time of extubation (T4) <br/ ><br>5 min after extubation <br/ ><br>(T5) <br/ ><br>10 min after extubation <br/ ><br>(T6) <br/ ><br>30 min after extubation <br/ ><br>(T7);VAS scoreTimepoint: 1 hr after extubation, <br/ ><br>2 hrs after extubation, and <br/ ><br>12 hrs after extubation