Evaluation of Circulating Tumor DNA as a Theranostic Marker in the Management of Glioblastomas.
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Presence of a correlation between the molecular abnormalities of the primary tumor and the circulating tumor DNA
研究概览
简要总结
Glioblastomas (GBM) are rare tumors of poor prognosis and their treatment is based on surgery followed by radiochemotherapy. Clinical and imaging evaluation is not always straightforward: the more or less complete surgery, the pseudo-progression after radiochemotherapy, the radionecrosis, the diagnosis of the relapse and the follow-up under anti-angiogenic can pose problems Clinicians and radiologists. Accessibility to a plasma tumor molecular marker would greatly facilitate the follow-up of these patients.
It is now established for many cancers that circulating tumor DNA (cTNA) has the same molecular abnormalities as those identified in the primary tumor cells. Numerous studies have shown the prognostic value and diagnosis of the exploration of cDNA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with grade IV glial tumor (glioblastoma according to WHO criteria) for which an indication of surgical excision with radiochemotherapy was chosen at a specialized multidisciplinary meeting of neuro-oncology at the CHU Amiens-Picardy.
- •Patients should:
- •be able to be followed at the CHU of Amiens throughout their treatment,
- •be at least 18 years of age,
- •be informed (or trusted) of the conditions and objectives of the study,
- •having given their free and informed consent in writing,
- •have a life expectancy of more than 6 months,
- •be affiliated to a social security scheme.
排除标准
- •Patients with recurrent tumors.
- •Patients supported for another histology.
- •Medical, psychological or social conditions that do not allow for proper understanding of the procedures inherent in the study.
- •Patients under tutelage, curatorship.
结局指标
主要结局
Presence of a correlation between the molecular abnormalities of the primary tumor and the circulating tumor DNA
时间窗: 1 year
次要结局
未报告次要终点