Molecular Mechanisms of Fibrillin/LTBP Superfamily in Renal Fibrosis and Cardiorenal Syndrome
Recruiting
- Conditions
- Renal Fibrosis, CKD
- Registration Number
- NCT05012228
- Lead Sponsor
- National Taiwan University Hospital
- Brief Summary
This project is to understand the LTBP4 expression in human renal fibrotic tissues. The investigators will exam major location of LTBP4 expression and check any similar or discrepancy in renal fibrosis with different etiologies.
- Detailed Description
The investigators will obtain the residual renal tissues with different etiologies and check the expression of LTBP4. The location and quantitation of LTBP4 in renal tissues will be checked. It will be great to understand the association between the severity of fibrosis and the expression of LTBP4 and other matrix proteins.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Abnormal kidney function, proteinuria, hematuria
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Exclusion Criteria
- N/A
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Expression of LTBP4 in human renal fibrotic tissue 5 years Expression of biomarkers in human renal fibrotic tissue 5 years Potential markers: eg. ROS-related proteins (8-oxodG, 4-HNE)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
National Taiwan University Hospital
🇨🇳Taipei, Taiwan