Insulin Resistance and Substrate Metabolism After Acute Erythropoietin (EPO) Administration

Not Applicable

Completed

• Conditions: Insulin Sensitivity
• Interventions: Drug: placebo (saline); Drug: erythropoietin

• Registration Number: NCT00793767
• Lead Sponsor: Aarhus University Hospital

Brief Summary

Recently EPO receptors have been found in human muscle tissue, but what is still not known is the physiological role of these receptors. In this study the researchers want to investigate if there is any effect of a acute administration of EPO on insulin resistance and/or substrate metabolism in muscle tissue.

Detailed Description

Recently EPO receptors have been found in human muscle tissue, but what is still not known is what the physiological role of these receptors are. It has previously been shown that Growth Hormone mediate insulin resistance. The GH receptor and EPO receptor belong to the same family of cytokine receptors, and thereby share many of the same signalling pathways. In this study we want to investigate if there is a similar effect on insulin resistance and/or substrate metabolism after acute administration of EPO in human muscle tissue. Different signalling pathways are investigated på western blotting, and insulin sensitivity are measured be a hyperinsulinemic euglycemic clamp, and substrate metabolism is measured by the forearm model.

Study Timeline

• Study First Submitted: 2008-11-18
• Study First Submitted QC: 2008-11-18
• Study First Posted: 2008-11-19
• Study Start: 2009-01
• Primary Completion: 2009-04
• Status Verified: 2009-05
• Last Update Submitted: 2009-05-28
• Last Update Posted: 2009-05-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

• Healthy persons
• Between 18 and 30 years
• Normal weight (BMI: 18-25)

Exclusion Criteria

• Severe heart disease (NYHA 3)
• Uncontrolled hypertension
• Previous cerebrovascular disease
• Proliferative retinopathy
• Diabetes
• Musculo-skeletal diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
placebo	placebo (saline)	placebo
Erythropoietin	erythropoietin	acute administration of erythropoietin

Primary Outcome Measures

Name	Time	Method
Insulin sensitivity	4 and 6 hours post

Secondary Outcome Measures

Name	Time	Method
Substrate metabolism	4 and 6 hours post

Trial Locations

Locations (1)

Medicinsk forsknings laboratorium; 🇩🇰 Århus C, Denmark