The study to compare the duration of action and efficacy of masseteric muscle bite force reduction and wrinkle treatment from different types of botulinum toxin A injectio

Phase 4

Completed

• Conditions: Healthy human volunteers; Botulinum Toxins, Injections, Intramuscular

• Registration Number: TCTR20211205001
• Lead Sponsor: Dermatologic Surgery, Dermatology department, Siriraj hospital, Thailand

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-12-05
• Study Completion: 2022-05-17
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Healthy male or female volunteers age 25-45 years, 2. No history of botulinum toxin treatment failure, 3. No history of immunodeficiency disease or taking any immunosuppressive drug, 4. Have masseter muscle prominent

Exclusion Criteria

1. pregnant or lactating woman, 2. Was treated with botulinum toxin during 6 months prior, 3. Having the skin disease around the treated area 4. Using an energy-based device or other interventions 6 months prior

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bite force Before intervention, 14 days, 1, 2, 3, 4, 5 and 6 months after the intervention Bite force will be measured by HBM Norge AS in neuton,wrinkle improvement scale Before intervention, 14 days, 1, 2, 3, 4, 5 and 6 months after the intervention Antera3d will be used to measure periorbital wrinkles,Physicians assessment score 14 days, 1, 2, 3, 4, 5 and 6 months after the intervention percentage of Physicians assessment score,Subject self assessment score 14 days, 1, 2, 3, 4, 5 and 6 months after the intervention percentage of Subject self assessment score

Secondary Outcome Measures

Name	Time	Method
Pain score immediate after the intervention Visual analogue scale (0-10)