Continued Mechanical Ventilation During CABG Operation Attenuates Systemic Immune Modulation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Coronary Artery Disease
- Sponsor
- Medical University of Vienna
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Alteration of soluble ST2 concentration in serum
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Cardiopulmonary bypass (CPB) is well known to induce a strong anti-inflammatory response. The investigators examined whether continued mechanical ventilation during CPB alters systemic immune activation.
Detailed Description
Cardiopulmonary bypass is well known to induce a strong anti-inflammatory response. Studies had been shown that the contact of blood components with artificial surfaces, the surgical trauma, endotoxemia and a reperfusion injury are in part responsible for the seen immunological affect after surgery. The purpose of this study is to test the effect of continued mechanical ventilation during surgery on a blood marker called soluble ST2 in patients sera. Soluble ST2 acts as a decoy receptor of IL-33 and has anti-inflammatory effects. Elevated soluble ST2 concentrations are reported in patients with acute myocardial infarction, sepsis, congestive heart failure and elevates soluble ST2 levels are associated with adverse outcome.
Investigators
Hendrik Jan Ankersmit
Assoc. Prof
Medical University of Vienna
Eligibility Criteria
Inclusion Criteria
- •Written informed consent
- •age \> 40 and \< 80
Exclusion Criteria
- •treatment with steroids or immunomodulatory interventions during the past four weeks
- •signs of an acute infection
Outcomes
Primary Outcomes
Alteration of soluble ST2 concentration in serum
Time Frame: Preoperative, postoperative, day 1, day 2, day 3, day 4, day 5 after surgery
Concentration of soluble ST2 will be assessed in the serum of patient´s preoperativem, postoperative and the following five consecutive days after surgery.