Preoperative Serum FGF19 in the Prognosis of Biliary Atresia
- Conditions
- Biliary AtresiaPrognosis
- Registration Number
- NCT05848310
- Lead Sponsor
- Children's Hospital of Fudan University
- Brief Summary
To investigate the role of preoperative serum FGF19 level in the prognosis of biliary atresia.
- Detailed Description
Kasai portoenterostomy is currently one of the main treatment methods for biliary atresia, but about 30% of children still require liver transplantation even after receiving the surgery. Accurate prognosis will help select the most suitable treatment method for children, but there is currently a lack of effective preoperative predictive indicators. Serum FGF19 has recently been considered a possible preoperative predictive indicator for biliary atresia, but its predictive value has not been confirmed in a large sample and in Asian population, thus the investigators try to further explore the prognostic value of serum FGF19 in children with biliary atresia based on a large sample.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 200
- Samples diagnosed as biliary atresia in Children's Hospital of Fudan University
- Samples with one-year follow-up records after surgery
- Samples with a record of serum total bilirubin levels three months after surgery
- Samples with preoperative serum left（volume > 500ul)
- None
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum total bilirubin level (umol/l) Three months after surgery The difference of serum total bilirubin level will be measured with ELISA( Enzyme Linked ImmunoSorbent Assay) three months after surgery
Native liver survival (%) One year after surgery The difference of native liver survival will be measured according to the follow-up statue one year after surgery
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Children's Hospital of Fudan University
🇨🇳Shanghai, Shanghai, China