Bioavailability of phenolics from olive leaf extract.
- Conditions
- pharmacokinetics of oleuropein metabolites
- Registration Number
- NL-OMON21153
- Lead Sponsor
- BioActor BV
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 16
Inclusion Criteria
GROUP 1:
1. Premenopausal women between 18 and 75 years old;
Exclusion Criteria
1. Clinically significant abnormal liver functioning (serum alanine and aspartate aminotransferase);
2. Clinically significant abnormal serum creatinin;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Concentrations of oleuropein metabolites in plasma and urine over 24h upon single dose administration of olive leaf extract standardized on oleuropein.
- Secondary Outcome Measures
Name Time Method 1. Differences in pharmacokinetic profiles between pre- and postmenopausal women;<br /><br>2. Activity of circulating oleuropein metabolites towards bone metabolism markers in ex vivo assay.