Effect of Aloe Vera Gel as an Intra Canal Medicament

Not Applicable

Completed

• Conditions: Periapical Diseases
• Interventions: Biological: Aloe vera Gel

• Registration Number: NCT06243601
• Lead Sponsor: Islamabad Medical and Dental College

Brief Summary

This research will overview the effect of aloe vera gel (AVG) as intra canal medicament in patients with asymptomatic periapical lesions. It will provide endodontists with scientific evidence regarding the beneficial use of AVG as an intracanal medicament owing to its superior antibacterial and analgesic properties as compared to routinely used commercial intra canal medicaments.

Detailed Description

Objective: To evaluate the effect of aloe vera gel based on clinical signs and symptoms as an intracanal medicament in asymptomatic periapical lesions over a period of three weeks. Methodology: Fresh AVG will be prepared. It will be placed as intracanal medicament after cleaning and shaping in patients with asymptomatic periapical lesions in group A while in group B (control group) no intracanal medicament will be placed. Patients will be randomly divided into two groups by randomization in Statistical Package for Social Sciences software (SPSS v24.0). They will be recalled for one week and three week follow ups and in case of no clinical signs and symptoms endodontic procedure will be completed. Statistical analysis: Descriptive statistics will be used for reporting age. Frequencies and percentages will be calculated for categorical variables and intergroup comparison will be done by chi square test

Study Timeline

• Study Start: 2023-11-30
• Study First Submitted: 2024-01-29
• Study First Submitted QC: 2024-01-29
• Study First Posted: 2024-02-06
• Primary Completion: 2024-08-20
• Study Completion: 2024-11-15
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-16
• Last Update Posted: 2025-05-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Both male and female patients presenting with asymptomatic periapical lesions in permanent teeth

Exclusion Criteria

• History of allergy to AVG

  • Comorbidities likely to impair healing
  • Pregnant women
  • History of previous endodontic treatment in the same tooth
  • Presence of pulp calcification
  • Internal or external root resorption

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
Intervention Group	Aloe vera Gel	Fresh AVG will be prepared. It will be placed as intracanal medicament after cleaning and shaping in patients with asymptomatic periapical lesions

Primary Outcome Measures

Name	Time	Method
Presence or absence of signs and symptoms of the patient	One week and 3 weeks	Patients in both the groups will be recalled after one week. They will be assessed clinically for either presence or absence of signs and symptoms.; 1. In cases of absence of clinical signs and symptoms, endodontic treatment will be completed.; 2. In cases where patient returns with presence of clinical signs and symptoms, dressing will be removed, and canals will be irrigated with sodium hypochlorite followed by saline. After drying the canals, in group A, AVG will be placed in the canals and tooth restored temporarily while in group B, cotton pellet will be placed in the canals and tooth restored temporarily. The patients will be recalled after two weeks.; 3. If a patient reports with acute symptomsin either of the groups, the protocols to manage acute infection will be followed.

Trial Locations

Locations (1)

Islamabad Dental Hospital; 🇵🇰 Islamabad, Federal, Pakistan