Aloe vera leaf

Overview

Aloe describes a genus including over 500 species of flowering succulent plants that grow in the Southern peninsula and various islands. Aloe vera, or Aloe barbadensis miller, is the most common species of Aloe that is cultivated for agricultural and medical purposes. It is a perennial succulent xerophyte with elongated leaves that contain a clear gel. While aloe vera has a long history of commercial uses, it is still widely used in cosmetic, food and pharmaceutical products. The use of aloe vera in constipation, inflammatory disorders, cancer, ulcer, and diabetes has also been investigated . The active constituents of aloe vera include polysaccharides with protective effects on skin, as they exhibit antioxidant and anti-inflammatory properties . Common active polysaccharides include glucomannans, polymannose, and acemannan, or b-(1–4)-acetylated polymannose . Acemannan and other modified polysaccharides are responsible in preventing suppression of contact hypersensitivity or immune suppression induced by external factors such as irradiation .

Indication

Indicated for use as a topical agent to soothe sensitive skin and to relieve symptoms of various skin conditions, including contact or atopic dermatitis, eczema, dermatitis and acne urticata, first- and second-degree burns, radiation dermatitis, and sunburn.

Associated Conditions

Acne
Atopic Dermatitis
Contact dermatitis and other eczema
Dermatosis
Folliculitis
Intertrigo
Lichen simplex chronicus
Moniliasis
Nummular Dermatitis
Pruritus Ani
Pyoderma
Stasis dermatitis
Disseminated Neurodermatitis
Genital pruritus
Localized Neurodermatitis

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Evaluation of the Efficacy of Aloe-Vera el Versus Bezydamine Hydrochloride in the Prevention of Radiation Induced Oral Mucositis A Randamized Controlled Clinical Trial	2025/03/17	NCT06879366	Phase 4	Completed	October 6 University
Comparison Between the Effect of Aloe Vera and Benzydamine Hydrochloride Mouth Gel on Prevention of Pain and Progression of Radiation-induced Oral Mucositis	2025/03/06	NCT06862817	Phase 1	Completed	Minia University
Effect of Aloe Vera Gel as an Intra Canal Medicament	2024/02/06	NCT06243601	Not Applicable	Completed	Islamabad Medical and Dental College
Flurbiprofen Versus Aloe Vera Gel in the Treatment of Chronic Periodontitis in Smoking Patients.	2023/09/18	NCT06041178	Phase 4	Completed	Beirut Arab University
RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF ENEMA ALOE VERA GEL IN ACTIVE ULCERATIVE PROCTOSIGMOIDITIS.	2021/02/15	NCT04753775	Not Applicable	Completed	Ospedale Sandro Pertini, Roma
The Effect of Toothpaste Containing Aloe Vera on Gingivitis	2020/12/10	NCT04662385	Phase 2	Completed	Zainab J Abbas
Effect of Aloe Vera Mouthwashes on the Oral Health of Children	2019/07/05	NCT04009616	Not Applicable	Completed	Damascus University
Local Host Modulating Agents Alendronate & Aloe Vera for Treatment of Furcation Defects in Chronic Periodontitis	2017/06/29	NCT03204097	Phase 2	Completed	Government Dental College and Research Institute, Bangalore
Role of Aloe Vera Versus Fluoride Toothpaste in Changing High to Low Salivary Bacterial Count	2017/04/11	NCT03108313	Phase 2	UNKNOWN	Cairo University
A Trial of Topical Aloe Vera Gel in Emergency Department Patients Presenting With Simple Traumatic Wounds	2016/06/30	NCT02819817	Phase 1	Withdrawn	NHS Lothian

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Immu-n Waker	Newton Laboratories, Inc.	55714-2596	ORAL	15 [hp_X] in 1 mL	5/21/2025
Immu-n Waker	Newton Laboratories, Inc.	55714-4862	ORAL	15 [hp_X] in 1 mL	5/21/2025
Aloquin	Primus Pharmaceuticals	68040-706	TOPICAL	10 mg in 1 g	10/7/2009
Alcortin A	Primus Pharmaceuticals	68040-705	TOPICAL	10 mg in 1 g	10/30/2009
IODOQUINOL HYDROCORTISONE ACETATE ALOE POLYSACCHARIDES	Syntenza Pharmaceuticals LLC	72056-020	TOPICAL	10 mg in 1 g	5/6/2020
Reduce Lip Lines	Guangzhou Yapeng Refinement Chemical Co., Ltd.	84356-007	TOPICAL	13 g in 100 g	6/20/2025
Shame	Deseret Biologicals, Inc.	43742-2276	ORAL	8 [hp_X] in 1 mL	5/7/2025
I-Waker	Newton Laboratories, Inc.	55714-4838	ORAL	15 [hp_X] in 1 mL	5/21/2025
WOWDAY MEDICATED HEMORRHOIDAL FLUSHABLE WIPES	Shanghai Tongjie Commodity Co.,Ltd.	85511-001	TOPICAL	10 mg in 100 mg	4/9/2025
Aquaflora High Potency 9	King Bio Inc.	57955-1814	ORAL	12 [hp_X] in 236 mL	5/20/2025

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
SANKAIJO TABLET	SATO PHARMACEUTICAL CO., LTD. HSINCHU FACTORY	SIN03486P	TABLET, FILM COATED	12.5 mg	6/24/1989

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
NutriVital Premium Gut Support Complex	326954	Nutrivital Pty Ltd	Medicine	A	12/2/2019
Overnight Cleanse	344734	Internal Healing Pty Ltd	Medicine	A	9/28/2020
Gut Calm + Restore	444372	Mind Gut Co Pty Ltd	Medicine	A	3/25/2024
YHL PREMIUM SHEEP PLACENTA 50000	353749	Universal Pharmaceuticals Pty Ltd	Medicine	A	1/28/2021
ATHELITE LAVA JOINT & MUSCLE PAIN RELIEF CREAM	429411	Twisobell Health Pty Ltd	Medicine	A	12/1/2023
Athelite Infinity Queen Women’s Pain Relief Spray	412170	Twisobell Health Pty Ltd	Medicine	A	7/3/2023
Arborvitae ModeX	407405	Arborvitae Health and Wellbeing Pty Ltd	Medicine	A	4/6/2023
Phys10 Ultra Armour Joint and Muscle Pain Relief Spray	484428	Twisobell Health Pty Ltd	Medicine	A	3/27/2025
Biogenic Aloe Vera Juice	80030	Lifestream International Pty Ltd	Medicine	A	8/23/2001
Bioeffective (R) Gel	168983	Prenolica Ltd	Medicine	A	2/11/2010

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
HOMEOPATHIC MEDICINE (S NO. 249) DPS 30C	total health centre	02077043	Drops - Oral	30 C / ML	12/31/1994
UNDA 46	seroyal international inc.	02233262	Liquid , Drops , Granules , Pellet , Tablet - Oral	10 X	4/6/1998
SEPIA COMPOSE DPS	laboratoires holis inc.	01934422	Drops - Oral	3 CH / DH	12/31/1984
ALOE SOCOTRINA GRANULE 1DH-30DH	homeocan inc.	00855545	Tablet - Oral	1 DH	12/31/1991
ALOE	seroyal international inc.	02233083	Drops , Tablet , Liquid , Pellet , Granules , Globules - Oral	1 X	4/6/1998
ALOE GOUTTE 4CH-30CH	dolisos laboratoires s.a.	00680486	Drops - Oral	2 CH / CH	12/31/1987
ONE TIME COMPOUND BENZOIN TCT F466	ACME UNITED CORPORATION	00518301	Stick - Topical	2 %	12/31/1979
HP5 TAB	METAGENICS, INC.	01975870	Tablet - Oral	3 X	10/4/1996
ALSIDOZ TAB	alsi cie ltee	00393665	Tablet - Oral	16.25 MG	12/31/1977
ALOE GRANULE 1DH - 30CH	dolisos laboratoires s.a.	00698962	Tablet - Oral	1 DH / DH	12/31/1987

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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