Evaluation of opioid free anaesthetic technique with lignocaine and magnesium sulphate infusion for laparoscopic cholecystectomy
Phase 1
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2021/04/032520
- Lead Sponsor
- Sir Ganga Ram Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. ASA Grade I, II
2. Laparoscopic cholecystectomy
Exclusion Criteria
Inability to obtain informed consent.
1. Patients on chronic use of opioid or beta blockers.
2. Known case of severe mental impairment.
3. Known allergy to study medication.
4. Inability to comprehend pain assessment preoperatively.
5. History of alcohol, drug abuse.
6. Received opioid medication within 24 hours before operation.
7. Pregnant or breast-feeding females.
8. Patients with cardiac, hepatic and renal insufficiency.
9. Patients with difficult airway.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome measure: <br/ ><br>Postoperative analgesic consumption till 24hrs/ discharge or patient need. <br/ ><br>Secondary outcome measure: <br/ ><br>1. Intraoperative <br/ ><br>a. Haemodynamic stability <br/ ><br>2. Postoperative: <br/ ><br>a. Pain scores at time points. <br/ ><br>b. Nausea and vomiting (PONV) <br/ ><br>c. Recovery time from general anaesthesia.Timepoint: Primary outcome measure: <br/ ><br>Postoperative analgesic consumption till 24hrs/ discharge or patient need. <br/ ><br>Secondary outcome measure: <br/ ><br>1. Intraoperative <br/ ><br>a. Haemodynamic stability <br/ ><br>2. Postoperative: <br/ ><br>a. Pain scores at time points. <br/ ><br>b. Nausea and vomiting (PONV) <br/ ><br>c. Recovery time from general anaesthesia.
- Secondary Outcome Measures
Name Time Method In patients undergoing laparoscopic cholecystectomy under general anaesthesia, to compare following outcomes with use of fentanyl versus lignocaine and magnesium sulphate: <br/ ><br>1.Intraoperative haemodynamics stability. <br/ ><br>2.Incidence of postoperative nausea and vomiting. <br/ ><br>3.Recovery time from general anaesthesia. <br/ ><br>Timepoint: Intraoperative to postoperative till discharge