Benefit of different drug combinations in decreasing pain during and after gall bladder removal surgery
Phase 4
Completed
- Conditions
- Health Condition 1: K801- Calculus of gallbladder with othercholecystitisHealth Condition 2: K80- Cholelithiasis
- Registration Number
- CTRI/2023/01/049236
- Lead Sponsor
- Department of Anaesthesia and Intensive care
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
1. Body mass index (BMI): 18-35 kg.m-2
2. Patients having American Society of Anaesthesiologists (ASA) Grade I-II
3. Patients scheduled to undergo laparoscopic cholecystectomy
Exclusion Criteria
1. Cardiac conduction abnormalities and congestive heart failure
2. Renal or hepatic impairment
3. Neurological disorders
4. Pregnant and lactating women
5. Patients not able to understand VAS
6. History of substance abuse
7. Contraindications to study drugs: lignocaine, ketorolac, magnesium
8. Chronic pain conditions, neurodegenerative or autoimmune disorders
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain at rest and movementTimepoint: baseline, post extubation, in postoperative care unit (PACU), at1, 6, 8, 12 and 24 h postoperatively.
- Secondary Outcome Measures
Name Time Method ength of hospital admissionTimepoint: Time of discharge;Serum lactate levels and ABG parametersTimepoint: baseline before surgery, intraoperative before extubation, postoperative at 6 h and 24 h;Time to first rescue analgesiaTimepoint: time of first drug intake in 24 h;Total intraoperative morphine used, time to first rescue and total analgesia in PACU and in postoperative periodTimepoint: 24 hours;adverse effectsTimepoint: during entire duration of study;Haemodynamic parameters (PR, BP, RR)Timepoint: baseline, at time of induction, after intubation, every 10 minutes during surgery, at time of extubation, every 5 minutes for 15 minutes, then every 15 minutes up to 60 minutes in PACU, and at 6, 8 ,12 and 24 hours