NCT06718972招募中不适用
Database of Real-world Study on the Treatment of Non-small Cell Lung Cancer With Leptomeningeal Metastasis in China
Guangzhou Medical University2 个研究点 分布在 1 个国家目标入组 1,000 人开始时间: 2024年9月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 2
- 主要终点
- Overall survival(OS)
研究概览
简要总结
This is a retrospective and prospective study planned to include NSCLC patients with Leptomeningeal metastasis (LM) and treated with antitumor therapy after 2018, from multiple centers such as the First Affiliated Hospital of Guangzhou Medical University, Guangdong Sanjiu Brain Hospital, etc., aiming to establish a database related to the treatment strategies of LM patients, and to evaluate the efficacy (eg. Overall Survival/Time to Failure) and safety of different treatment strategies of LM patients, etc., as well as the significance of concomitant testing in LM patients.
详细描述
retrospective and prospective study
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •non-small cell lung cancer patients with Leptomeningeal metastases diagnosed after January 2018;
- •Patients who underwent antitumor therapy after diagnosis of LM.
排除标准
- •Patients with small cell lung cancer components;
- •complicated with tumors other than non-small cell lung cancer.
结局指标
主要结局
Overall survival(OS)
时间窗: 6 years
次要结局
- Time to failure(TTF)(6 years)
- Change in cerebrospinal fluid and metabolic markers during treatment(6 years)
- Safety during actual clinical treatment(6 years)
研究者
Haihong Yang, MD, Pricipal investigator
Chief Physician
Guangzhou Medical University
研究点 (2)
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