ISRCTN17251494已完成3 期
Stopping Perioperative Angiotensin II Converting Enzyme inhibitors and/or angiotensin receptor blockers in major non-cardiac surgery (SPACE): A phase III, mechanistic, randomised controlled trial
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 260
研究概览
简要总结
2023 Results article in https://doi.org/10.1093/eurheartj/ehad716 (added 12/12/2023)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Informed consent (no incapacitated or vulnerable adult or minors will be included)
- •2. Currently taking angiotensin converting enzyme inhibitors and/or angiotensin receptor blockers therapy
- •3. Age 60 years and over
- •4. Patients undergoing major surgery (major joint replacement/ vascular/ gastrointestinal) requiring general anesthesia that is expected to take longer than 120 minutes
- •5. American Society of Anesthesiologists grade 3 or above
排除标准
- •1. Current participation in any other trials
- •2. Recent myocardial infarction (within 3 months)
- •3. Any condition, which in the opinion of the treating clinician would result in the patient being harmed by the cessation of the angiotensin II converting enzyme inhibitors and/or angiotensin receptor blockers therapy
研究者
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