Stopping perioperative angiotensin II converting enzyme inhibitors and/or angiotensin receptor blockers in major noncardiac surgery

Phase 3

Completed

• Conditions: Patients undergoing major surgery requiring general anaesthesia; Surgery

• Registration Number: ISRCTN17251494
• Lead Sponsor: Queen Mary University of London

Brief Summary

2023 Results article in https://doi.org/10.1093/eurheartj/ehad716 (added 12/12/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-05-29
• Study Completion: 2022-06-30
• Last Update Posted: 8 January 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 260

Inclusion Criteria

1. Informed consent (no incapacitated or vulnerable adult or minors will be included)
2. Currently taking angiotensin converting enzyme inhibitors and/or angiotensin receptor blockers therapy
3. Age 60 years and over
4. Patients undergoing major surgery (major joint replacement/ vascular/ gastrointestinal) requiring general anesthesia that is expected to take longer than 120 minutes
5. American Society of Anesthesiologists grade 3 or above

Exclusion Criteria

1. Current participation in any other trials
2. Recent myocardial infarction (within 3 months)
3. Any condition, which in the opinion of the treating clinician would result in the patient being harmed by the cessation of the angiotensin II converting enzyme inhibitors and/or angiotensin receptor blockers therapy

Study & Design

• Study Type: Interventional
• Study Design: Not specified