Response to angiotensin II in formerly preeclamptic women. RETAP study.

Completed

• Conditions: preeclampsie, zwangerschap; kidney disease; preeclampsia; 10038430

• Registration Number: NL-OMON36569
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

- Healthy females with history of normotensive pregnancy, with a range of one to five years after their pregnancy.
- Females with a history of severe preeclampsia, with a range of one to five years after their pregnancy

Exclusion Criteria

Diabetes mellitus
Diabetes gravidarum
BMI >= 30
Oral contraceptive pill use which can*t be temporally stopped
Participants with renal diseases
Participants with cardiovascular diseases
Treatment with anti-hypertensive drug
Blood pressure: systolic > 150, diastolic > 100 mmHg
Pregnant or lactating women
Any surgical or medical condition that in the opinion of the investigator would jeopardize the evaluation of efficacy or safety

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoint of this study is the renal response (GFR, ERPF and FF)<br /><br>to angiotensin II in formerly preeclamptic women compared to healthy controls. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To evaluate the difference in systemic response (blood pressure) to angiotensin<br /><br>II<br /><br>To evaluate the difference in response to sodium intake in relation to blood<br /><br>pressure and renal function<br /><br>To evaluate absolute renal function determined as GFR, ERPF and FF.<br /><br>To evaluate the difference in response to sodium intake on plasma values of<br /><br>markers of renin-angiotensin system activity, including angiotensin II,<br /><br>aldosteron, angiotensin converting enzyme activity and plasma renin activity.<br /><br>To evaluate the gender differences in renal and blood pressure response to<br /><br>different sodium intakes and angiotensin II infusion. </p><br>