Response to angiotensin II in formerly preeclamptic women. RETAP study.
- Conditions
- Formerly preeclamptic women
- Registration Number
- NL-OMON26813
- Lead Sponsor
- niversity Medical Center Groningen
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
1. Healthy females with a history of normotensive pregnancy; with a range of one to five years after their pregnancy;
2. Participants with a history of severe preeclampsia; with a range of one to five years after their pregnancy;
Exclusion Criteria
1. Diabetes mellitus;
2. Diabetes gravidarum in healthy females groups;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary endpoints will be renal (ERPF, GFR and FF) response and systemic response (bloodpressure) to angiotensin II after low and high sodium diet in formerly preeclamptic patients compared to healthy controls. <br>
- Secondary Outcome Measures
Name Time Method Secondary endpoints will be renal function after preeclampsia, expressed as glomerular filtration rate (GFR), effective renal plasma flow (ERPF), filtration fraction (FF) and extracellular volume (ECV) and changes in RAAS-parameters (plasma renine activity, aldosteron, angiotensins, ACE-activity) in relation to sodiumintake, in formely preeclamptic patients compared to healthy controls.