An evaluation of the effect of an angiotensin-converting enzyme (ACE) inhibitor on the growth rate of small abdominal aortic aneurysms - Evaluation of effect of ACE inhibitors on small aneurysm growth rate
- Conditions
- Abdominal Aortic AneurysmsMedDRA version: 14.0Level: LLTClassification code 10000054Term: Abdominal aortic aneurysmSystem Organ Class: 10047065 - Vascular disorders
- Registration Number
- EUCTR2010-020226-17-GB
- Lead Sponsor
- Imperial College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 225
All men or women, aged 60 or greater years, with AAA <5.5 cm and with a systolic BP <150mmHg will be eligible for inclusion in the trial. For patients whose systolic BP is >150mmHg, treatment will be initiated with a diuretic Indapamide SR 1.5mgs by the principal investigator and/or amlodipine (5mg daily) initiated by the general Practitioner. If the SBP subsequently falls to <150mmHg on this medication subjects would then be eligible for inclusion into the study.
Are the trial subjects under 18? no
Number of subjects for this age range: 0
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 0
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 0
Patients already receiving an ACE-inhibitor or amlodipine 10mg daily or an angiotensin II receptor blocker drug (ARB) who cannot be converted to diuretic therapy and/or lower doses of amlodipine for treatment of their blood pressure. Patients with known renal artery stenosis (>50%). Patients with baseline serum creatinine >180 Those unable to give informed consent and those too frail to travel for 3-monthly surveillance.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method