Comparison of effects of combined angiotensin converting enzyme inhibitor and low dose thiazide diuretic on insulin action in patients with hypertension and type two diabetes: a double-blind crossover study
Completed
- Conditions
- Type two diabetes and essential hypertensionNutritional, Metabolic, EndocrineDiabetes
- Registration Number
- ISRCTN41655008
- Lead Sponsor
- Royal Victoria Hospital (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 15
Inclusion Criteria
1. Aged 40 to 65 years
2. Hypertension (either newly diagnosed or controlled on treatment)
3. Type two diabetes established on dietary treatment with or without oral hypoglycaemic agents
4. Fasting plasma glucose in the range 7 - 12 mmol/l
Exclusion Criteria
1. Secondary hypertension
2. Hepatic or renal disease or were taking Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or steroids which may affect insulin action
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method When compared to captopril alone, treatment with low dose bendroflumethiaizide (1.25 mg) in combination with captopril produced a 23% reduction in glucose infusion rates required to maintain isoglycaemia and there was a comparable reduction in isotopically induced decline in peripheral insulin sensitivity most probably in skeletal muscle. The combination of low-dose bendroflumethiazide 1.25 mg and captopril resulted in a significant reduction in blood pressure (6/3 mmHg) compared to captopril alone.
- Secondary Outcome Measures
Name Time Method Serum potassium was significantly lower after treatment with captopril and bendroflumethiaizide as compared to treatment with captopril alone.