A comparison of a combination drug of an angiotensin II receptor antagonist and a low-dose diuretic vs combination therapy with an angiotensin II receptor antagonist and a calcium channel blocker in hypertensive patients with metabolic syndrome

Phase 4

• Conditions: Hypertension with metabolic syndrome

• Registration Number: JPRN-UMIN000001238
• Lead Sponsor: Hypertension in Metabolic syndrome CHIBA (HMS-CHIBA) Study group

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-07-10
• Study Completion: 2009-03-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Sex: Male
• Target Recruitment: 200

Inclusion Criteria

Not provided

Exclusion Criteria

1) Patients with uncontrolled hypertension (diastolic blood pressure ≥ 110mmHg) 2) Patients with malignant hypertension 3) Patients with uncontrolled diabetes (HbA1c ≥8.0%) 4) Patients with uncontrolled hypertriglyceridemia (TG ≥400mg/dL) 5) Patients who have stroke, AMI and/or critical vascular complications that required hospitalization within 6 months prior to the intervention 6) Patients with liver dysfunction [GPT(ALT) over three times the normal value] 7) Patients with renal failure (serum creatinine ≥2.0 mg/dL) 8) Patients with a previous history of gout attack or uncontrolled hyperuricemia (≥8.0mg/dL) 9) Patients under treatment with insulin 10) Pregnant or breast feeding female patients, including one trying to conceive pregnancy during the planned study period 11) Patients with uncontrolled arhythmia 12) Patients with severe valvular disease including mitral stenosis and incompetence of aortic valve 13) Patients with cardiac insufficiency (NYHA grade III or IV) 14) Patients with a history of hypersensitivity to ingredients of losartan potassium 15) Patients with a history of hypersensitivity to thiazide or thiazide-like diuretics 16) Patients with a history of hypersensitivity to ingredients of dihydropyridines 17) Patients who are considered not eligible for the study by the attending doctor due to medical reasons

Study & Design

• Study Type: Interventional
• Study Design: Not specified