NCT02958514已完成不适用
Efficacy Comparison of Two Kinds of Treatment in Treating Dry Eye Caused by Meibomian Gland Dysfunction
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 主要终点
- Ocular Surface Disease Index (OSDI)
研究概览
简要总结
This study aims to evaluate the efficacy of intense pulsed light in treating dry eye caused by meibomian gland dysfunction and make a comparison between the traditional treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 26 Years 至 78 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with dry eye syndrome and diagnosed as MGD
排除标准
- •an infection or inflammatory disease;
- •ocular surgical history with in the last 3 months
- •SGOGREN SYNDROME
研究组 & 干预措施
traditional treatment group
Other
Subjects in this group are treated by tobramycin and dexamethasone ophthalmic ointment qn and artificial tears qid.
干预措施: Tobramycin and Dexamethasone Ophthalmic Ointment (Drug)
IPL treatment group
Experimental
Subjects in this group are treated with 3 cycles of intense pulsed light of 4 weeks interval and artificial tears qid.
干预措施: intense pulsed light (Device)
结局指标
主要结局
Ocular Surface Disease Index (OSDI)
时间窗: through study completion,an average of 6 months
normal value：\<13 abnormal value：≥ 13
次要结局
- Corneal Fluorescein Stain(CFS)(through study completion,an average of 6 months)
- Eyelid ester discharge ability score(through study completion,an average of 6 months)
- Eyelid ester trait ratings(through study completion,an average of 6 months)
- breakup time of tear film （BUT）(through study completion,an average of 6 months)
- The concentrations of inflammatory cytokines such as IL-1、IL-6 and IL-8(through study completion,an average of 6 months)
研究者
Hong Qi
MD.PHD.
Peking University Third Hospital
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