Efficacy Comparison of Two Kinds of Treatment in Treating Dry Eye Caused by Meibomian Gland Dysfunction

Not Applicable

Completed

• Conditions: Dry Eye Syndrome
• Interventions: Drug: Tobramycin and Dexamethasone Ophthalmic Ointment; Device: intense pulsed light

• Registration Number: NCT02958514
• Lead Sponsor: Peking University Third Hospital

Brief Summary

This study aims to evaluate the efficacy of intense pulsed light in treating dry eye caused by meibomian gland dysfunction and make a comparison between the traditional treatment.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-10-03
• Study Start: 2016-11
• Study First Submitted QC: 2016-11-04
• Study First Posted: 2016-11-08
• Primary Completion: 2017-02
• Study Completion: 2017-03
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-01
• Last Update Posted: 2022-05-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• patients with dry eye syndrome and diagnosed as MGD

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Exclusion Criteria

• an infection or inflammatory disease;
• ocular surgical history with in the last 3 months
• SGOGREN SYNDROME

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
traditional treatment group	Tobramycin and Dexamethasone Ophthalmic Ointment	Subjects in this group are treated by tobramycin and dexamethasone ophthalmic ointment qn and artificial tears qid.
IPL treatment group	intense pulsed light	Subjects in this group are treated with 3 cycles of intense pulsed light of 4 weeks interval and artificial tears qid.

Primary Outcome Measures

Name	Time	Method
Ocular Surface Disease Index (OSDI)	through study completion,an average of 6 months	normal value：\<13 abnormal value：≥ 13

Secondary Outcome Measures

Name	Time	Method
Corneal Fluorescein Stain(CFS)	through study completion,an average of 6 months
Eyelid ester discharge ability score	through study completion,an average of 6 months
Eyelid ester trait ratings	through study completion,an average of 6 months
breakup time of tear film （BUT）	through study completion,an average of 6 months	normal value：\>10s abnormal value：≤ 10s
The concentrations of inflammatory cytokines such as IL-1、IL-6 and IL-8	through study completion,an average of 6 months