Comparison of Hyperemic Efficacy Between Central and Peripheral Adenosine Infusion for Fractional Flow Reserve (FFR) Measurement
Phase 4
Completed
- Conditions
- Coronary Artery DiseaseMyocardial Ischemia
- Interventions
- Other: FFR via central venous lineOther: FFR via peripheral venous line
- Registration Number
- NCT01070420
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
The purpose of this study is to evaluate the safety and effectiveness of the peripheral IV continuous infusion without the insertion of central venous vascular access method in the achievement of steady-state maximal coronary hyperemia compared with the central IV continuous infusion method.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 66
Inclusion Criteria
- non -infarct related, patients with moderate coronary artery stenosis
- normal ejection fraction on echocardiogram
Exclusion Criteria
- infarct-related arteries or clinically unstable state
- collateral blood flow to the target vessel is shown
- atrioventricular block on electrocardiogram
- reduced ejection fraction(<50%) or left ventricular hypertrophy on echocardiography
- contraindication of adenosine
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description FFR via central venous line FFR via central venous line - FFR via peripheral vein FFR via peripheral venous line -
- Primary Outcome Measures
Name Time Method compare fractional flow reserve at maximal hyperemia interval of 10 minutes
- Secondary Outcome Measures
Name Time Method compare the time to maximal hyperemia and changes in heart rate interval of 10 minutes
Trial Locations
- Locations (1)
Cardiovascular Center, Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of