Preservation of metabolic flexibility by acetylcarnitine formatio

Completed

• Conditions: non-insulin dependant diabetes; type 2 diabetes mellitus; 10018424

• Registration Number: NL-OMON41675
• Lead Sponsor: Maastricht Universitair Medisch Centrum + (MUMC+)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 72

Inclusion Criteria

Body mass index (BMI): 25-35, age: 40-70, Hb value > 7.8mmol/l, generally healthy (no medication use that interferes with metabolic parameters under investigation)

Exclusion Criteria

contra-indication voor MRI, anemia, plasma creatinine conc > 115micromol/l (men) and > 100 micromol/l (women), high blood pressure (>140 mm Hg (systolic) or >90 (diastolic)), fasting plasma glucose > 7,0 mmol/L

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>metabolic flexibility<br /><br>insulin sensitivity<br /><br>maximal acetyl carnitine formation<br /><br>activity of enzyme carnitine acyl transferase (CrAT)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n/a</p><br>