Hypotensive Effects of Conventional Dairy Products: Role of Arterial Stiffness

Not Applicable

Completed

• Conditions: Prehypertension; Stage-1 Hypertension
• Interventions: Dietary Supplement: Non-fat dairy; Dietary Supplement: Add 4 servings fruit

• Registration Number: NCT01577030
• Lead Sponsor: University of Texas at Austin

Brief Summary

Elevated systolic blood pressure is by far the largest single contributor to cardiovascular risks in middle-aged and older adults. Lifestyle modifications, including dietary modifications, are the first line approach for treating and preventing hypertension. The general aim of the proposed study is to address the efficacy of conventional dairy products as part of the normal routine diet for lowing arterial blood pressure in middle-aged and older adults with elevated blood pressure. The investigators hypothesize that the dietary intervention including dairy products will induce significant decreases in arterial blood pressure in this population. A secondary aim will be to test the hypothesis that these reductions in systolic blood pressure will be associated with increases in arterial stiffness/compliance and endothelial vasodilatory function.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2012-04-10
• Study First Submitted QC: 2012-04-11
• Study First Posted: 2012-04-13
• Primary Completion: 2013-10
• Study Completion: 2013-11
• Status Verified: 2014-02
• Last Update Submitted: 2014-02-10
• Last Update Posted: 2014-02-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 49

Inclusion Criteria

• Prehypertension or stage-1 hypertension

Exclusion Criteria

• Consume > 3 servings of dairy or fruit per day
• Strenuous physical activity > 3 time per week
• Lactose intolerance, pregnancy, lactation, and/or alcohol abuse
• Taking cardiovascular-acting drugs
• Overt cardiovascular disease, metabolic disease, GI disorders and/or renal disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Dairy	Non-fat dairy	Add 4 daily servings of non-fat dairy to diet for a period of 4 weeks
Fruit	Add 4 servings fruit	Add 4 daily servings of fruit to diet, remove all dairy from diet for a period of 4 weeks

Primary Outcome Measures

Name	Time	Method
Seated blood pressure	4 weeks

Secondary Outcome Measures

Name	Time	Method
24-hour ambulatory blood pressure	4 weeks
Carotid arterial compliance	4 weeks
Arterial stiffness	4 weeks
Flow mediated dilation	4 weeks

Trial Locations

Locations (1)

The University of Texas at Austin, Cardiovascular Aging Research Laboratory; 🇺🇸 Austin, Texas, United States