Hypotensive Effects of Conventional Dairy Products: Role of Arterial Stiffness
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 49
- 试验地点
- 2
- 主要终点
- Seated blood pressure
研究概览
简要总结
Elevated systolic blood pressure is by far the largest single contributor to cardiovascular risks in middle-aged and older adults. Lifestyle modifications, including dietary modifications, are the first line approach for treating and preventing hypertension. The general aim of the proposed study is to address the efficacy of conventional dairy products as part of the normal routine diet for lowing arterial blood pressure in middle-aged and older adults with elevated blood pressure. The investigators hypothesize that the dietary intervention including dairy products will induce significant decreases in arterial blood pressure in this population. A secondary aim will be to test the hypothesis that these reductions in systolic blood pressure will be associated with increases in arterial stiffness/compliance and endothelial vasodilatory function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 35 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Prehypertension or stage-1 hypertension
排除标准
- •Consume > 3 servings of dairy or fruit per day
- •Strenuous physical activity > 3 time per week
- •Lactose intolerance, pregnancy, lactation, and/or alcohol abuse
- •Taking cardiovascular-acting drugs
- •Overt cardiovascular disease, metabolic disease, GI disorders and/or renal disease
结局指标
主要结局
Seated blood pressure
时间窗: 4 weeks
次要结局
- 24-hour ambulatory blood pressure(4 weeks)
- Carotid arterial compliance(4 weeks)
- Arterial stiffness(4 weeks)
- Flow mediated dilation(4 weeks)