EFFECTIVENESS OF SINGLE DOSE VERSUS MULTIDOSE INTRA ARTICULAR INJECTION OF PLATELET RICH PLASMA IN EARLY OSTEOARTHRITIS OF KNEE - A RANDOMISED CONTROL SINGLE BLIND TRIA

Sri Sathya Sai Institute of Higher Medical Sciences Prasanthigram0 个研究点目标入组 90 人开始时间: 待定最近更新: 2021年11月24日

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•1)Grade 1, Grade 2 OA knee as per Kellgren - Lawrence radiographic staging.
•2) Patients who give consent for treatment with platelet rich plasma as per our protocol.
•3) Patients with stable knees, normal tibiofemoral alignment,or patellofemoral tracking.

•1) Osteoarthritis secondary to joint inflammatory diseases (eg- rheumatoid arthritis, ankylosing spondylitis etc).
•2)Patients with other diseases, affecting the knee joint like crystal arthropathy, symptomatic chondrocalcinosis, acute synovitis, excessive joint effusion( >100ml), cystic disease around the knee joint(eg-popliteal cyst).
•3) Patients with generalized osteoarthritis.
•4) Metabolic disease of the bone.
•5) Patients with co-existing low back ache.
•6) Late stages of osteoarthritis.
•7) Intra articular injections within the previous three months.
•8) Pertaining to platelet concentrate use - h/o thrombocytopenia, use of anticoagulant therapy, active infection, malignancies.
•9) Patients with abnormal leucocyte count.
•10) Patients with blood diseases, systemic metabolic, immunodeficiency state.
•11) Local or generalised infection.
•12)Varus-valgus malalignment above 5Â°, patellofemoral maltracking or untreated instability.
•13)History of prior arthroscopic or surgical intervention of knee.
•14) Treatment with corticosteroids < 3 months or medication < 7 days that could interfere with platelet aggregation.

发起方

Sri Sathya Sai Institute of Higher Medical Sciences Prasanthigram