Efficacy of a Single dose versus Triple Dose Regimen of Mebendazole against Hookworm infection among School Children: Randomized trial.

niversity of Gondar0 个研究点目标入组 108 人开始时间: 2019年11月26日最近更新: 2023年5月29日

试验速览

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•Written informed consent signed by parents and/or legal guardians; and a verbal assent (children <18 years) according to Ethiopian regulation.
•Able and willing to be examined by a study physician at the beginning of the study.
•Able and willing to provide required stool samples at the beginning (baseline) and two to three weeks after treatment (follow-up).
•Positive for hookworm eggs in the stool.
•No recent anthelminthic treatment (within past 4 weeks).
•Negative pregnancy test (girls =12 years)
•Apparently health individual; based on medical history, physical examination, vital signs, hemoglobin level were included
•Children who were able to chew the drug were subjected for randomization
•Participant had hemoglobin level above 8g/dl

•Individual who has taken any form of medication containing mebendazole or any other treatment for STH infection within 30 days of entry into the study
•Who had diarrhea at the time of the first sampling,
•Who experience a severe concurrent medical condition,
•Participant with haemoglobin level below 8g/dl,
•Child with known history of allergic reaction to mebendazole, and
•Participants infected with other parasitic infection were excluded from the allocated treatment

发起方

niversity of Gondar