Study of change of blood pressure and heart rate response to placement of tube into windpipe by an instrument to see voice box inside throat by giving tablet Ivabradine (heart rate lowering medication) and tablet Clonidine (decreases heart rate)

Phase 4

Registration Number: CTRI/2023/08/055936

Lead Sponsor: Sri Manakula Vinayagar Medical College and Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Patient should be of age 18-60 yrs.

Patient to get fit under ASA PS I and II

Patient should undergo Elective non cardiac surgery under General Anesthesia

Exclusion Criteria

Patient who refused to give consent for study.

Patient with known hypersensitivity to these study drugs.

Baseline Heart rate less than 60

Baseline systolic Bp less than 100.

Those with ECG abnormalities.

Patients with history of chest pain/palpitations/syncope,

Patients with history of any visual disturbances, with Sick sinus syndrome.

Patients already on calcium channel blockers, azole antifungals, antiretroviral drugs and macrolide antibiotics, with hepatic impairment or renal dysfunction, pregnant and breastfeeding females and

Patients in whom intubation is thought to be difficult (time taken to intubate >

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To the best of literature . There is no study evaluating the hemodynamic attenuation of laryngoscope <br/ ><br>and endotracheal intubation comparing oral ivabradine & oral clonidine & with the previous <br/ ><br>studies & previous records .however studies have done between clonidine vs gabapentin & ivabradine alone. <br/ ><br>Timepoint: Laryngoscopic response till 5 minutes

Secondary Outcome Measures

Name	Time	Method
1.To the study the effect of these drugs on hemodynamic during intra operative & post operative <br/ ><br>Period . <br/ ><br>2.To study about the side effects & complications such as visual disturbances , arrhythmias, etc <br/ ><br> , if any due to the study drugs. <br/ ><br>Timepoint: At baseline ,1 hr , 2hrs , 3hrs , one week