Quadratus Lumborum Block for Analgesia After Living Donor Kidney Transplantation: A Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Analgesia
- Sponsor
- Seoul National University Hospital
- Enrollment
- 88
- Locations
- 1
- Primary Endpoint
- Analgesic consumption for 24 postoperative hours
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The aim of this study is to evaluate the postoperative analgesic effect of quadratus lumborum block in patient undergoing a living donor kidney transplant under general anesthesia.
Detailed Description
The purpose of this study was to investigate whether postoperative pain is significantly reduced when TQL block was additionally performed after surgery in patients undergoing living-donor kidney transplantation. Therefore, investigator hypothesized that the analgesic consumption for postoperative 24 hours will decrease in TQL group compared to the control group. For secondary outcomes, the pain score at rest/ movement up to 48 hours after surgery, the time until the first pain reliever is requested, whether and how often rescue analgesics are administered for 48 hours, the incidence and severity of nausea and vomiting during the 48 hours after surgery, patient's satisfaction with post-pain control and the number of hospital stays were investigated. Overall, the aim of this study is to evaluate the postoperative analgesic effect of quadratus lumborum block in patients undergoing a living donor kidney transplantation under general anesthesia.
Investigators
Sun-Kyung Park
Clinical Assistant Professor
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients over 19 years of age undergoing elective living donor kidney transplantation under general anesthesia in Seoul National University Hospital
Exclusion Criteria
- •Patients with severe pain before surgery
- •Patients with a history hypersensitivity reactions on fentanyl or ropivacaine
- •Patients who cannot maintain patient-controlled analgesia (PCA) by themselves
- •④ Patients with skin diseases or infections in the area where quadratus lumborum block is applied
- •⑤ Any other cases that researchers determine that it is inappropriate for this clinical trial
Outcomes
Primary Outcomes
Analgesic consumption for 24 postoperative hours
Time Frame: 24 hours postoperatively
Total analgesic use for 24 hours after surgery (morphine milligram equivalents (MME))
Secondary Outcomes
- Analgesic consumption(at postoperative 6, 12, 48 hours)
- Sensory blockade(30 minutes after the end of operation)
- Resting pain numeric rating scale(NRS)(at postoperative 6, 12, 24, 48 hours)
- Numeric rating scale of pain during movement(at postoperative 6, 12, 24, 48 hours)
- Time to first rescue analgesics(within post-operative 24 hours)
- Numeric rating scale at post anesthetic care unit (PACU)(30 minutes after the end of operation)
- Rescue analgesics administration(within post-operative 48 hours)
- The incidence of post-operative nausea and vomiting(within post-operative 48 hours)
- Patient satisfaction with pain control(At post-operative 48 hours)
- Pattern of injectate spread on ultrasonography(During procedure quadratus lumborum (QL) block)
- Quality of Recovery Questionnaire (15-item Quality of Recovery)(At post-operative 48 hours)
- The severity of post-operative nausea and vomiting(within post-operative 48 hours)