LODS Role in Predicting 30-day Mortality Outcome in ICU
- Conditions
- Mortality
- Interventions
- Other: Logistic Organ Dysfunction System Score
- Registration Number
- NCT03930160
- Lead Sponsor
- Indonesia University
- Brief Summary
LODS score for deceased ICU patients within 30 days is higher than survived ICU patients
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 439
- adult patient (age 18 years and above) admitted to ICU
- patients admitted to ICU due to burn injury, coronary artery disease, post cardiac surgery
- patients with incomplete required information for LODS score
- patients deceased or discharged less than 24 hours of admission
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Mortality outcome Logistic Organ Dysfunction System Score -
- Primary Outcome Measures
Name Time Method Correlation between LODS score variables with patient outcome 30 days from admission Correlation between patient outcomes with each LODS score variables: GCS; heart rate; systolic BP; blood urea; serum creatinine; urine output; leucocyte count; platelet count; PaO2/FiO2; serum bilirubin; prothrombin time.
LODS score discrimination ability 30 days from admission LODS score ability to discriminate patient outcomes based on variables of logistic organ dysfunction system scores: GCS; heart rate; systolic BP; blood urea; serum creatinine; urine output; leucocyte count; platelet count; PaO2/FiO2; serum bilirubin; prothrombin time.
LODS score calibration 30 days from admission LODS score ability to predict patient outcomes based on variables of logistic organ dysfunction system scores: GCS; heart rate; systolic BP; blood urea; serum creatinine; urine output; leucocyte count; platelet count; PaO2/FiO2; serum bilirubin; prothrombin time.
- Secondary Outcome Measures
Name Time Method LODS neurologic variable score: Glasgow Coma Scale (GCS) Day 1 The score for GCS variable cutoff:
0 point for 14-15;
1 point for 9-13; 3 points for 6-8; 5 points for 3-5.LODS cardiovascular variable score: Heart rate (HR) and/or systolic blood pressure (SBP) Day 1 The score for HR (in bpm) and/or SBP (in mmHg) variable cutoff:
0 point for HR 30-139 and SBP 90-239;
1 point for SBP 70-89 or 240-269 or HR \>=140; 3 points for SBP 40-69 or \>=270; 5 points for HR \<30 or SBP \<40.LODS pulmonary variable score: Partial oxygen pressure (PaO2)/Fraction of inspired oxygen (FiO2) on Mechanical Ventilation (MV) or Continuous Positive Airway Pressure (CPAP) Day 1 The score for PaO2/FiO2 (in mmHg/%) variable cutoff:
0 point for no ventilation and no CPAP;
1 point for \>=150; 3 points for \<150.Patient outcome 30 days from admission Patient outcome within 30 days of admission to intensive care unit (ICU): deceased or survived
LODS hematologic variable score: white blood cell (WBC) count and/or platelet count Day 1 The score for WBC (in x10\^3/L) and/or platelet count in (x10\^3/L) variable cutoff:
0 point for WBC 2.5-49.9 and platelet \>=50;
1 point for WBC 1.0-2.4 or \>=50.0 OR platelet \<50; 3 points for WBC \<1.0LODS renal variable score: serum urea nitrogen (BUN) and/or creatinine and/or urine output (UO) Day 1 The score for BUN (in mg/dL) and/or creatinine (in mg/dL) and/or UO (in litres/day) variable cutoff:
0 point for BUN \<17 AND creatinine \<1.20 AND UO 0.75-9.99;
1 point for BUN 17-\<28 OR creatinine 1.20-1.59; 3 points for BUN 28-\<56 AND creatinine \<1.60 AND UO 0.5-0.74 or \>=10; 5 points for BUN \>=56 OR UO 0.5.LODS hepatic function variable score: Serum Bilirubin and/or Prothrombin time (PT) Day 1 The score for serum bilirubin (in mg/dL) and/or PT (in % of standard) variable cutoff:
0 point for bilirubin \<2.0 and PT \>=25;
1 point for bilirubin \>=2.0 OR PT\<25% or \>3.
Trial Locations
- Locations (1)
Rumah Sakit Cipto Mangunkusumo
🇮🇩Jakarta Pusat, DKI Jakarta, Indonesia